The Theophano Imperial Palace is located on a hill on the Kassandra peninsula and is just steps from Kallithea Beach. The hotel is 45 minutes from the center of Thessaloniki. The Macedonia airport is just 70 kilometers (35 minutes) from the Theophano Imperial Palace. During their stay, guests can make use of the area's bus system to get around, rent a car, or take a taxi to their destinations.

All of the Theophano Imperial Palace’s 100 guestrooms and 48 suites feature satellite television, air conditioning, in-room safes, refrigerators, and direct dial telephones. Suites also have private terraces.

A De Luce hotel, the Theophano Imperial Palace features gardens that overlook the Toroneos Gulf. On-site amenities include an outdoor pool, free wireless Internet access throughout the hotel, a Kids Club that includes a special menu for children and animated entertainment, 6 tennis courts, mini golf, water and beach aerobics, as well as a variety of other water sports. There is also a professional diving center that guests can access.